Zinc status in infants and children with cholestatic liver diseases and its effect on growth

Abstract

The mean initial serum zinc (± SD) in cholestatic and healthy control group was 1251 ± 558 and 1461 ± 506 ug/l, respectively (P > 0.05). Meanwhile, serum IGF1 median (IQR; range) in patients and control was 54 (118;10:780) ng/ml and 250 (387;55:635) ng/ml, respectively (p < 0.001). No statistically significant difference was found between post-Kasai patients and other cholestatic diseases. Children supplemented with zinc had their serum zinc 2223 ± 1042 ug/l (P < 0.001) and IGF1 median (IQR; range) 346 (370;50:825) ng/ml (P < 0.001). In addition, among anthropometric variables, height (length) Z-score and percentile were significantly improved (P < 0.01).