Item Infomation

Title: Micronutrients and many important factors that affect the physiological functions of toll-like receptors
Authors: El-Zayat, Salwa Refat
Participants: Sibaii, Hiba
Mannaa, Fathia A.
Issue Date: 2019
Series/Report no.: Bulletin of the National Research Centre, Vol 43:123 (2019)
Abstract: Toll-like receptors (TLRs) are type I integral transmembrane receptors involved in recognition and conveying of pathogens to the immune system. These receptors are located either on cell surfaces or within endosomes. They are activated by specific ligand leading to the release of cytokines via signal transduction pathway. The excess production of these cytokines leads to disrupt the immune homeostasis. There are several factors regulating TLR expression and consequently affecting their functions. Among these are inflammation, cytokines, some cellular process, air pollution, depression, stress, some drugs, genetic polymorphism, nutrition, and micronutrients. Some micronutrients (vitamins and trace elements) may be considered as important TLR regulators, as they have immunomodulatory functions. Vitamins D, B12, and A; zinc; copper; and iron have important role on innate immune responses.
ISSN: 2522-8307
Appears in Collections:Tài liệu mở




Files in This Item:
There are no files associated with this item.

Bạn đọc là cán bộ, giáo viên, sinh viên của Trường Đại học Thuỷ Lợi cần đăng nhập để Xem trực tuyến/Tải về

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.