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Authors: Bokolia, Naveen Prakash; Advisor: -; Participants: Gadepalli, Ravisekhar (2023) - Previous research investigation determined the abundance levels of subgenomic RNAs from the COVID-19 patient samples (Alexandersen et al. 2020). Authors mapped the NGS reads data to subgenomic RNAs in order to identify the abundance of particular subgenomic RNA from the patient samples (Alexandersen et al. 2020). NGS reads mapped results revealed that Orf7a and N subgenomic were in high abundance, whereas Orf8, Orf6, and E subgenomic were relatively low (in an increasing order). These subgenomic RNAs are present several fold higher in comparison with whole genome fragments. Therefore, the present study seek to identify the possible conserved regions nearby the TRS or initiation codon ...
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Authors: Atalay, Merve; Advisor: -; Participants: Şen, Başak; Erden, Didem Dayangaç (2023) - Cystic fibrosis is an autosomal recessive genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene. The CFTR gene has been mapped to 7q31.2 (Navarro 2016). Today, more than 2000 mutations have been identified in the CFTR gene which varies depending on ethnicity (The Clinical and Functional TRanslation of CFTR (CFTR2)). Mutations detected in Turkish population are genetically heterogeneous and different from European populations. In Europe, incidence rates ranging from 1:2800 to 1:10,000 have been reported, while incidence in Asia has greater variance between countries, ranging from 1:5800 in Bahrain to 1:350,000 in Japan (Scotet et al. 2020). As a...
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Authors: Zhou, Guichi; Advisor: -; Participants: Wang, Lulu; Tang, Xue; Liu, Shilin; Li, Tonghui; Liu, Yi; Chen, Fen; Mai, Huirong; Liu, Sixi; Wen, Feiqiu; Wang, Ying (2023) - Acute lymphoblastic leukemia (ALL) is a critical hematological cancer, making up 75–80% of all pediatric acute leukemia cases (Alvarnas et al. 2012). Although advanced chemotherapy regimens are highly efficient in pediatric ALL, approximately 15–20% of cases eventually relapse, while 8–10% die from disease progression or treatment-related complications (Nguyen et al. 2008). ALL is common in children with hematological cancers in China. Although China has made substantial progress treating pediatric ALL(Chen et al. 2021), more effective and less toxic approaches to treat young patients with relapsed/refractory ALL (R/R ALL) are still urgently needed
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Authors: Mohamed I. Abo-Alkasem,; Advisor: -; Participants: Hassan, Ne’mat H.; Elsoud, Mostafa Mostafa Abo (2023) - The world accelerated industrial revolution and the uses of natural resources during metal mining and industry have a great impact on the environment due to heavy metal pollution. Today, one of the most destructive effects facing the world is the contamination with heavy metals, which reaches the air, soil, and water (Asha and Sandeep 2013; Raghunandan et al. 2014, 2018). Although trace concentrations of some metals have a vital effect on the health of living organisms, high levels of heavy metals represent toxic effects too (Ahemad 2019; Ahuti 2015). Also, heavy metals can hardly be degraded in the soil, so their complete detoxification represents a challenge to scientists. Despite t...
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Authors: Seyoum, Wasihun; Advisor: -; Participants: Tora, Ephrem (2023) - About 83 reported articles were retrieved and sorted from various database sources. Twenty of the articles were excluded during the initial screening due to inappropriateness of abstract and title by manual tracing. Further, 63 articles were subjected to inclusion criteria. Among these, 27 articles were removed due to the presence of an unrepresentative sample, redundancy of reports and inadequate methodology. Inadequate methodology includes poor sampling strategy, data management and presentation of results. The remaining 36 articles were again tested for sample size and 9 articles were dropped due to small sample size where the studies were only based on molecular characterization. ...
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Authors: Chakraborty, Prasenjit; Advisor: -; Participants: Kumar, Randhir; Karn, Sanjay; Srivastava, Ankit Kumar; Mondal, Priya (2023) - In early December 2019, an unusual pneumonia outbreak in Wuhan city, China, created an unprecedented and irreversible impact on the entire world 2/24/2023 12:58:00 PM. The symptoms of COVID-19 range from mild to severe, and include mainly fever, cough, and respiratory distress. Severe cases of pneumonia and hypoxemia result in considerable mortality (Rothan and Byrareddy 2020). The etiology has been linked to the new strain of coronavirus (SARS-CoV-2). According to the COVID-19 weekly epidemiological update by the World Health Organization (WHO), as of 9 May 2021, there have been a total of 163,965,336 COVID-19 cases with 3,397,147 fatalities (World Health Organization 2021). However,...
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Authors: Kalariya, Kuldeepsingh A.; Advisor: -; Participants: Shahi, Deep; Meena, Ram Prasnna; Gajbhiye, Narendra; Sarkar, Rohan; Geetha, K. A.; Saran, Parmeshwar Lal (2023) - Weather parameters during the crop period revealed that there was evaporative demand of 22.6 mm and 23.4 mm in the crop year 2019 and 2020, respectively, during the stress period. Bright sunshine hours were 56.6 and 59.1 during the stress period in the crop years 2019 and 2020, respectively. The maximum temperature remained at 29.1 °C and 28.4 °C during the stress period in the crop year 2019 and 2020, respectively. The periodic measurement of soil moisture revealed that by stopping the irrigation, the soil moisture was depleted continuously and reached less than 6.0% in 50 days stress period (Fig. 1).
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Authors: Vinson, Colby; Advisor: -; Participants: Pavlovsky, Ethan; Loomis, Mario (2023) - Originating from the lumbar plexus, the typical course of the femoral nerve descends anterior to the iliacus, travels deep to the inguinal ligament, and then branches into anterior and posterior divisions responsible for innervating anterior thigh muscles (Fig. 1). Clinically, the spatial relationship of the iliopsoas complex and the femoral nerve has been described as an “entrapment-risk”, most often following medical or surgical interventions (Park et al. 2020). There have been differing symptoms reported from these previously reported variations. Documented symptoms related to variant femoral nerves include thigh weakness, thigh numbness, and difficulty standing
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Authors: Artsitas, Sotirios; Advisor: -; Participants: Artsitas, Dimitrios; Segkou, Ioanna; Koronaki, Irene; Toutouzas, Konstantinos G.; Zografos, George C. (2023) - Study retrieval and quality assessment
The literature search included all available comparative studies until April 2022. This process resulted in a total of 180 reports, of which 130 were retrieved from the “Google Scholar,” 45 from the “PubMed,” and 5 from the “CENTRAL” databases, respectively. Of this initial set of reports, 22 were excluded as duplicates, 46 were excluded due to incompatibility of their title with automated means, and 7 were excluded due to incompatibility of their title after a relevant evaluation by the authors. The above procedure resulted in 105 relevant reports toward the evaluation of their content. Of these, 24 were excluded due to unavailable text, result...
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Authors: Mahran, Abeer Hashem; Advisor: -; Participants: Fahmy, Sarah Hossam; Ibrahim, Sarah Shokry (2023) - Characterization of the nanomaterials by TEM
Calcium phosphate nanoparticles
The well-crystallized Nano calcium phosphate particles were needle or rod-like, and their dimensions were approximately (110 ± 10) nm in length and (25 ± 5) nm in width, (Fig. 2).
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Authors: Mushi, Vivian; Advisor: -; Participants: - (2023) - Onchocerciasis, commonly known as river blindness, is an eye and skin parasitic disease caused by the filarial worm Onchocerca volvulus (O. volvulus) and transmitted by repeated bites of infected blackflies (Simulium species) (WHO 2022). Onchocerca species that infect domestic and wild animals, such as O. lupi, O. dewittei japonica, O. cervicalis, O. jakutensis, and O. gutturosa, have been reported to infect humans in 40 cases with clinical manifestations similar to those caused by O. volvulus (Cambra-Pellejà et al. 2020). Blackflies usually breed in fast-flowing and oxygen-rich streams and rivers hence the high prevalence of onchocerciasis in villages along or near the fast-flowing s...
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Authors: Abou- Seif, Howida Sayed; Advisor: -; Participants: Hozayen, Walaa Gamal (2023) - O. majorana alleviate Serum Liver Function Related Parameters in DXM treated rats
Table 1 illustrates liver damage which obviously appeared as a significant elevated activities (P < 0.0001) of circulating enzymes in serum (ALT, AST, ALP and LDH) after DXM treatment. Conversely, O. majorana pretreated animals successfully improved liver function markers which restored and/ or reduced these enzyme activities to normal level
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Authors: Chou, Wendy; Advisor: -; Participants: Alam, Saamia; Bracero, Lucas; Schabel, Joy; Bergese, Sergio; Costa,Ana (2023) - Neuraxial anesthesia is widely used for labor analgesia in the USA. Techniques such as epidural and combined spinal–epidural have been used in modern obstetric anesthesia practices for years. The dural puncture epidural (DPE) technique has shown to provide better sacral analgesia for patients in labor compared to epidural anesthesia, and with fewer maternal and fetal side effects compared to combined spinal–epidural technique
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Authors: Juliano Pacheco Abreu,; Advisor: -; Participants: Tholt, Beatriz; Molena, Kelly Fernanda; Pretel, Hermes; Veiga, Eugenia Velludo (2023) - Juvenile psammomatoid ossifying fibroma (JPOF) is a rare neoplasm belonging to a group of fibro-osseous lesions characterized by the replacement of normal bone tissue by fibrous tissue, containing foci of mineralization of varying shapes and amounts (Chrcanovic and Gomez 2020). Due to its specificity, it is classified as an osteogenic neoplasm with clinical and histological characteristics different from juvenile trabecular ossifying fibroma, predilection for age and specific locations (Ranganath et al. 2014; Chrcanovic and Gomez 2020). They most frequently affect the bones of the maxillofacial complex of children and adolescents, involving the paranasal sinuses, orbit, frontoethmoida...
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Authors: Isaza-Meza, Mariana; Advisor: -; Participants: Afanador-Rubio, Diana Carolina; Huérfano-Castro, Manuel Alejandro; Ramírez-Correa, Ivon; Flórez-Vargas, Adriana Alejandra (2023) - Anti-glomerular basement membrane (GBM) disease, also known as "Goodpasture syndrome," is an autoimmune vasculitis that affects small vessels through the deposit of IgG antibodies against the glomerular and alveolar basal membranes which are visualized as linear deposits in the GBM. The target of these autoantibodies is the non-collagen-1 domain of type IV collagen on the GBM, which presents changes in the structure of the α-345 hexamer, leading to a conformational change that triggers an autoimmune response (Gulati and McAdoo 2018). ANCA-associated vasculitis (AAVs) is a necrotizing vasculitis with few-to-none immune deposits, also affecting small vessels, and is associated with spec...
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Authors: Shedura, Vulstan James; Advisor: -; Participants: Mchau, Geofrey Joseph; Kamori, Doreen (2023) - Socio-demographic characteristics of the study participants
Between February 2022 and April 2022, a total of 220 pregnant women living with HIV in the Mtwara region were enrolled. The study participants' median age was 32.7 years (IQR 27.6–37.6). The majority, 34.1% (75/220) and 71.4% (157/220) of the participants were from Mkomaindo hospital and attained only a primary school level of education, respectively. 47.7% (105/220) were unemployed, 51.8% (114/220) were living in urban areas, and 45.5% (100/220) were married.
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Authors: Mahran, Abeer Hashem; Advisor: -; Participants: Fahmy, Sarah Hossam; Ibrahim, Sarah Shokry (2023) - Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted u...
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Authors: Babatope, Tolulope; Advisor: -; Participants: Ilyenkova, Vera; Marais, Debbi (2023) - A total of 161 records identified from the four databases were exported into Rayyan systematic review software and duplicates were removed, leaving 148 records to be screened (Fig. 2). The kappa test of inter-rater agreement between reviewers was 0.83. Full-text screening was conducted to further assess the remaining 23 articles for eligibility before data extraction. Eight articles were excluded mainly due to being the wrong publication type (n = 4) or having the wrong outcome (n = 4). At the end of the process, 15 articles were eligible for inclusion in the review with an inter-rater agreement of κ = 0.95.
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Authors: Reyes-Chaparro, A.; Advisor: -; Participants: Lopez, N. S. Flores-; Guerrero, F. Quintanilla-; Nicolás-Álvarez, Dulce Estefanía; Hernandez-Martinez, A. R. (2023) - A total of 10,100 chalcone-derived molecules were obtained (Additional files 1, 2, and 3); then different screening techniques were used for physicochemical properties, molecular docking, molecular dynamics, and DFT calculations to select the best candidates. Drugs used as MAO-A inhibitors were evaluated as a reference comparison.
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Authors: Madanagopal, Premnath; Advisor: -; Participants: Muthusamy, Sathya; Prince, Prabhu Rajaiah; Pradhan, Satya Narayan (2023) - Prediction of T cell epitopes and prioritization
In this study, CTL epitopes were predicted using the IEDB MHC-I processing tool, whereas HTL epitopes were predicted using the IEDB MHC-II Binding Predictions tool and both types of T cell epitopes were predicted by the SMM approach against a set of human reference HLAs with adjusted IC50 value less than 50 nM. A total of 15 CTL epitopes and 3 HTL epitopes were shortlisted for eight selected antigenic proteins by applying several immunological filters as shown in Tables 1 and 2. All of the optimal epitopes, as well as their antigenicity, positioning and binding alleles, are documented in Tables 3 and 4. In addition, for the best possib...
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