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  • An overview on COVID-19: reality and expectation

    • Authors: Hamed, Manal A.;  Advisor: -;  Participants: - (2020)

  • Under this emergency situation that the world facing against COVID-19, there are about 15 potential vaccine candidates tested globally based on messenger RNA, DNA-based, nanoparticle, synthetic, and modified virus-like particle. Certain drugs that are clinically approved for other diseases were tested against COVID-19 as chloroquine, hydroxychloroquine, ivermectin, favipiravir, ribavirin, and remdesivir. Convalescent plasma transfusion and traditional herbal medicine were also taken into consideration. Due to the absence of effective treatment or vaccines against COVID-19 so far, the precautionary measures according to WHO’s strategic objectives are the only way to confront this crisi...
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  • COVID-19 vaccines: their effectiveness against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its emerging variants

    • Authors: Noor, Rashed;  Advisor: -;  Participants: Shareen, Saadia; Billah, Muntasir (2022)

  • The world has been suffering from the COVID-19 pandemic (officially declared by WHO in March 2020), caused by the severe acute respiratory β-coronavirus 2 (SARS-CoV-2) since the last week of December 2019. The disease was initially designated as a Public Health Emergency of International Concern on January 30, 2020. In order to protect the health of mass public, an array of research on drugs and vaccines against SARS-CoV-2 has been conducted globally. However, the emerging variants of SARS-CoV-2, i.e., Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) variants which evolved in late 2020 and the Omicron variant (B.1.1.529) which emerged in November 2021 along with its...
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  • How do the severe acute respiratory coronavirus 2 (SARS-CoV-2) and its variants escape the host protective immunity and mediate pathogenesis?

    • Authors: Noor, Rashed;  Advisor: -;  Participants: - (2022)

  • Since the middle of March 2020, the serious health threat of this century so far has been caused by the severe acute respiratory syndrome γ coronavirus 2 (SARS-CoV-2), a ~ 30 kb RNA virus, which is also known as the 2019-nCoV coronavirus, a member of Nidovirales order of the family Flaviviridae, resulting in COVID-19 pandemic with 6,325,785 deaths out of 540,923,532 confirmed cases of COVID-19 so far (WHO 2022; Noor 2021a). As of 20 June 2022, a total of 11,912,594,538 vaccine doses have been administered (WHO 2022). SARS-CoV-2 originated from Wuhan, Hubei province of China in the last of December in 2019, and then spread around the world within three months as a consequence of the tr...