1H-NMR-based serum metabolomic study to evaluate the effect of asarone and metformin on experimentally induced diabetic hepatocellular carcinoma in rats

Abstract

The effect of asarone and metformin on serum glucose and lipid profile levels is illustrated in Table 2. The STZ- and STZ + DEN-induced rats showed significant elevation (p < 0.001) of serum glucose and lipid profile levels (TG, TC, and LDL-c) along with a decrease (p < 0.001) in HDL-c compared to the normal control group. Further, the treated groups significantly controlled the glucose and lipid profile levels compared to the STZ + DEN group. However, the variation of LDL-c and HDL-c levels in the asarone-treated group was not statistically significant.