Anticonvulsant activity and mechanism of actions of fractions of Ipomoea asarifolia (Desr) (Convolvulaceae) ethanol leaf extract

Abstract

Effects of fractions of n-hexane, chloroform, n-butanol and RAF of crude leaf extract of Ipomoea asarifolia on PTZ-induced seizures in mice Figure 2 shows the effects of fractions of chloroform, n-butanol, n-hexane and RAF of crude leaf extract of Ipomoea asarifolia on PTZ-induced seizures in mice. There n-hexane and chloroform could not protect the mice from the PTZ-induced seizures, while n-butanol at doses of 150 and 300 mg/kg and RAF at doses of 75 mg and 300 mg/kg have significantly (P < 0.01) delayed time onset of PTZ-induced seizures by increasing the mean onset time as compared to the standard. The standard control sodium valproate at 200 mg/kg completely protected the mice from seizure.