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Molecular targets and system biology approaches for drug repurposing against SARS-CoV-2

Authors: Singh, Rahul Kunwar; Advisor: -; Participants: Yadav, Brijesh Singh; Mohapatra, Tribhuvan Mohan (2020)

COVID-19, a pandemic declared by WHO, has infected about 39.5 million and killed about 1.1 million people throughout the world. There is the urgent need of more studies to identify the novel drug targets and the drug candidates against it to handle the situation.

How successful Bangladesh is in controlling the coronavirus pandemic?

Authors: Akanda, Ayatullah Al Musabi; Advisor: -; Participants: Ahmed, Redwan (2020)

The results show that simulated number of patients (without policy measures) surpassed the actual number of patients (with policy measures) from the first week of July 2020 which may provide a signal about the positive impact of policy measures taken by the government.

A proposed insight into the anti-viral potential of metallic nanoparticles against novel coronavirus disease-19 (COVID-19)

Authors: Fouad, Ghadha Ibrahim; Advisor: -; Participants: - (2021)

Emerging novel COVID-19 is a global health emergency on a pandemic scale that represents a terror to human health through its ability to escape anti-viral measures. Such viral infections impose a great socioeconomic burden, besides global health challenges. This imposes a pressing need for the development of anti-viral therapeutic agents and diagnostic tools that demonstrate multifunctional, target-specific, and non-toxic properties. Nanotheranostics is regarded as a promising approach for the management of different viral infections. Nanotheranostics facilitates targeted drug-delivery of anti-viral therapeutics as well as contributing to the development of diagnostic systems. Multifunctional metallic nanoparticles (NPs) have emerged as innovative theranostic agents that enable sust...

Evaluation of respiratory tract bacterial co-infections in SARS-CoV-2 patients with mild or asymptomatic infection in Lagos, Nigeria

Authors: Davies-Bolorunduro, Olabisi Flora; Advisor: -; Participants: Fowora, Muinah Adenike; Amoo, Olufemi Samuel; Adeniji, Esther; Osuolale, Kazeem Adewale; Oladele, Oluwatobi; Onuigbo, Tochukwu Ifeanyi; Obi, Josephine Chioma; Oraegbu, Joy; Ogundepo, Oluwatobi; Ahmed, Rahaman Ademolu; Usman, Olagoke AbdulRazaq; Iyapo, Bosede Ganiyat; Dada, Adedamola Adejuwon; Onyia, Ngozi; Adegbola, Richard Adebayo; Audu, Rosemary Ajuma; Salako, Babatunde Lawal (2022)

A common complication of any respiratory disease by a virus could be a secondary bacterial infection, which is known to cause an increase in severity. It is, however, not clear whether the presence of some opportunistic pathogens called pathobionts contributes to the severity of the disease. In COVID-19 patients, undetected bacterial co-infections may be associated with the severity of the disease. Therefore, we investigated the implications of bacterial co-infections in COVID-19 cases.

COVID-19: introduction of a new lifestyle and diet among the Malaysians

Authors: Pitol, Md. Najmus Sayadat; Advisor: -; Participants: Sapir, Ana Shakirah Md. (2023)

The stay-at-home conditions due to the COVID-19 pandemic significantly alter the Malaysian lifestyle, and all Malaysians faced difficulties adopting the new lifestyle. A hypothetico-deductive technique has been conducted in this study, to find out what kind of changes the COVID-19 has brought about in the behavior of Malaysians and how they are coping with the changing lifestyles. According to G* Power 3.1 sample size determination in Malaysia, the entire sample of 112 was sufficient to provide the value for the medium effect size for the computation of the F-tests and the findings were reliable (The Cronbach's alpha values were all above 0.70.). To calculate the mean of the lifestyle during COVID-19, the mean scores range between 1.00 and 5.00 marks indicating much reduced to much ...

COVID-19 and the call for ‘Safe Hands’: Challenges facing the under-resourced municipalities that lack potable water access - A case study of Chitungwiza municipality, Zimbabwe

Authors: Zvobgo, L.; Advisor: -; Participants: Do, P. (2020)

This paper proposes short- and long-term measures that would allow effective implementation of the ‘Safe Hands’ by means of sustainable potable water supply. These measures include extensive social awareness and temporary change of household water use behavior. Municipalities are recommended to establish public private partnerships (PPPs) to create immediate and long-term water investments. Structural and transformational reforms would enhance, through flexible planning, investments for both water infrastructure and governance. This narrative has the potential to improve the urban water systems resiliency against future pandemics.

Photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) in oral manifestations of patients infected by Sars-CoV-2: systematic review and meta-analysis

Authors: Pacheco, Juliano Abreu; Advisor: -; Participants: Molena, Kelly Fernanda; Martins, Camila Raíssa Oliveira Gontijo; Corona, Silmara Aparecida Milori; Borsatto, Maria Cristina (2022)

In 2019, a viral and respiratory pathology called COVID-19 emerged in Wuhan, China, and spread to other continents. Its main symptoms include fever, cough, dyspnea, myalgia, anorexia and respiratory distress in the most severe cases, which can lead to death. Furthermore, manifestations in the oral cavity such as ageusia and dysgeusia, as well as lesions in other regions of the oral cavity, can be observed.

The impact of COVID-19 on consumers' eating and purchasing habits of agricultural products in China: key determinants and policy implications

Authors: Udimal, Thomas Bilaliib; Advisor: -; Participants: Peng, Zhiyuan; Luo, Mingcan; Liu, Yan (2022)

The study looks at a changed in consumer’s eating and purchasing habits during COVID-19 period. There are several modes of transmission but transmission through food as being speculated is one area that has not been confirmed through research. The study, therefore, looks at how speculations about COVID-19 spreading through food has affected consumers' eating and purchasing habits. This study through probit model analysed how consumers' eating and purchasing habits have been influenced.

Bulletin of the National Research Centre, Volume 46 (2022), Article number: 240

Authors: Aurora, Fabienne; Advisor: -; Participants: Arasaretnam, Anita; Hobkirk, Andrew (2022)

Acute Leukaemias are haematological disorders characterised by the proliferation of immature white blood cells in the bone marrow and/or peripheral blood. Oral manifestations of leukaemia are common and may be the first sign of the disease. The clinical presentation of these Acute Leukaemias may include neutropenic sepsis, hyperviscocity and coagulopathy which confer a potential morbidity and mortality. Clinicians must be able to recognise this pattern of presentation.

Protective and therapeutic potentials of HDL and ApoA1 in COVID-19 elderly and chronic illness patients

Authors: AbdelHafez, Mohamed Aly; Advisor: -; Participants: - (2022)

HDL has multiple physiological functions; i.e. reverse cholesterol transport, anti-inflammatory, anti-thrombotic, anti-oxidative, anti-apoptotic in addition to protection of vascular endothelium against damage and leakage of small particles like LDL to pass through. Apo-lipoprotein A1 (Apo-A1) is the main apo-lipoprotein component and plays an axial role in HDL function. Alterations of HDL disturb its functions. Elderly subjects, obese patiens, and patients with chronic illness such as diabetes, cardiovascular disease (CVD) or chronic inflammatory diseases have bad comorbidity among COVID19 patients. Inflammation affect HDL structure and function. COVID-19 causes systemic immune-inflammation due to cytokine explosion, viral interaction with erythrocytes and its hemoglobin content an...

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