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Authors: Muhammad, Yasin Ali; Advisor: -; Participants: - (2022) - At the time of this writing, SARS-CoV-2 has reportedly claimed the lives of millions of people worldwide. However, there is still disagreement concerning the origin of SARS-CoV-2, its true nature, and the extent of its pathogenicity. Thus, the purpose of this manuscript is to highlight and critically analyze these differences so that research efforts can be geared toward addressing these concerns.
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Authors: Choudhury, Priyanka Ray; Advisor: -; Participants: Saha, Tapoja; Goel, Sachin; Shah, Janvi Manish; Ganjewala, Deepak (2022) - The majority of pandemics are known to be a result of either bacteria or viruses out of which viruses seem to be an entity of growing concern due to the sheer number of yet unidentified and potentially threatening viruses, their ability to quickly evolve and transform, their ability to transfer and change from one host organism to another and the difficulty in creating safe vaccines on time.
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Authors: Giri, Simran; Advisor: -; Participants: Sen, Sanjukta; Singh, Rohan; Paul, Paramita; Sahu, Ranabir; Nandi, Gouranga; Dua, Tarun Kumar (2022) - The World Health Organization declared the outbreak of the novel coronavirus (COVID-19) as a global health emergency on January 30, 2020, and as a pandemic disease on March 11, 2020. This review highlights the international situation, risk factors, and related protections to be taken as prerequisite measures and probable treatment options for the COVID-19-infected population in the current scenario.
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Authors: Precious Ayorinde Akinnusi,; Advisor: -; Participants: Samuel Olawale Olubode,; Wasiu Adeboye Salaudeen, (2022) - The search for ideal drugs with absolute antiviral activity against SARS-CoV-2 is still in place, and attention has been recently drawn to natural products. Several molecular targets have been identified as points of therapeutic intervention. The targets used in this study include SARS-CoV-2 helicase, spike protein, RNA-dependent RNA polymerase, main protease, and human ACE-2. An integrative computer-aided approach, which includes molecular docking, pharmacophore modeling, and pharmacokinetic profiling, was employed to identify anthocyanins with robust multiple antiviral activities against these SARS-CoV-2 targets.
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Authors: Noor, Rashed; Advisor: -; Participants: Shareen, Saadia; Billah, Muntasir (2022) - The world has been suffering from the COVID-19 pandemic (officially declared by WHO in March 2020), caused by the severe acute respiratory β-coronavirus 2 (SARS-CoV-2) since the last week of December 2019. The disease was initially designated as a Public Health Emergency of International Concern on January 30, 2020. In order to protect the health of mass public, an array of research on drugs and vaccines against SARS-CoV-2 has been conducted globally. However, the emerging variants of SARS-CoV-2, i.e., Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) variants which evolved in late 2020 and the Omicron variant (B.1.1.529) which emerged in November 2021 along with its subvariant BA.2 which was first identified in India and South Africa in late December 2021, have ra...
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Authors: Davies-Bolorunduro, Olabisi Flora; Advisor: -; Participants: Fowora, Muinah Adenike; Amoo, Olufemi Samuel; Adeniji, Esther; Osuolale, Kazeem Adewale; Oladele, Oluwatobi; Onuigbo, Tochukwu Ifeanyi; Obi, Josephine Chioma; Oraegbu, Joy; Ogundepo, Oluwatobi; Ahmed, Rahaman Ademolu; Usman, Olagoke AbdulRazaq; Iyapo, Bosede Ganiyat; Dada, Adedamola Adejuwon; Onyia, Ngozi; Adegbola, Richard Adebayo; Audu, Rosemary Ajuma; Salako, Babatunde Lawal (2022) - A common complication of any respiratory disease by a virus could be a secondary bacterial infection, which is known to cause an increase in severity. It is, however, not clear whether the presence of some opportunistic pathogens called pathobionts contributes to the severity of the disease. In COVID-19 patients, undetected bacterial co-infections may be associated with the severity of the disease. Therefore, we investigated the implications of bacterial co-infections in COVID-19 cases.
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Authors: Adedeji, Akinbode A.; Advisor: -; Participants: Vijayakumar, Paul Priyesh (2022) - A direct quote from CDC’s Web site dated April 2021 reads, “It is possible for people to be infected (with SARS-CoV-2) through contact with contaminated surfaces or objects (fomites), but the risk is generally considered to be low.” How low the risk is, we do not know yet because there are no enough evidence-based empirical studies to support or counter this claim. Here is what we know, SAR-CoV-2, the virus that causes COVD-19 continues to pose a serious threat and has caused significant disruption to human activities, including food production since it became a pandemic in 2020. As of June 2022, 192 countries/regions have reported at least one case of the virus infection, and over 535 million cases have been reported globally (that is 294 million more since October 2021) with 85.5 ...
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Authors: Agarwal, Deepak; Advisor: -; Participants: Zafar, Imran; Ahmad, Syed Umair; Kumar, Sujit; Ain, Qurat ul; Sundaray, Jitendra Kumar; Rather, Mohd Ashraf (2022) - Ongoing pandemic outbreaks (COVID-19) and public health crises were intimidating across the globe with the appearance and spread of the 2019 novel coronavirus known as SARS-CoV-2. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) quickly spread from its origin in the Wuhan City of Hubei Province of the Republic of China, a country in East Asia, to the rest of the world (Wang et al. 2020a, b). Still, with small amounts of asymptomatic transmission between people, it spreads throughout the globe (Mohan et al. 2021). Coronaviruses (CoVs) are single-stranded, large, enveloped RNA viruses. They are spherical pleomorphic particles with bulbous surface projections. The CoVs genome size is from 29.8 to 29.9 kb (Su et al. 2016; Zheng et al. 2020). Virus particles have an average d...
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Authors: Goswami, Pritam; Advisor: -; Participants: Chatterjee, Debasmita; Ghosh, Sayak; Paira, Krishnendu; Das, Satadal (2022) - Delta SARS-CoV-2 spike protein RBD antigen, in concentration of 10 µg/mL, increases IFN-α, more than 1500 times. It also increases IFN-ß about 150 times, and TGF-ß about 74 times. Increase in IFN-ƴ, IL-6, IL-8, IL-10, and IL-1ß was insignificant.When after administration of Bryonia 6C, the chick embryo was challenged with antigen, only interferons are moderately upregulated along with IL-6. Although increase in interferons after 48 h is beneficial to the embryo, an increase in IL-6 may lead to initiation of upsurge of pro-inflammatory cytokines. This may be detrimental to the normal physiological activities of the embryo, and thus, the preventive role of Bryonia 6C is questionable. In the curative experiment after administration of antigen, and then challenging with Bryonia 6C, the ...
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