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Tác giả: Gustavsen, Stefan; Người hướng dẫn: -; Người tham gia: Nordling, Mette Maria; Weglewski, Arkadiusz (2023) - The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has been leading to dramatic health, social and economic problems around the world. It was necessary to introduce worldwide vaccination program against SARS-CoV-2 virus. Vaccination of billions of people around the world leads to many questions about risk of vaccines and possible side effects. It is well known that acute disseminated encephalomyelitis (ADEM) is a rare, but possible complication of vaccines. Previously, cases of ADEM following various COVID-19 vaccines, including the vaccines from AstraZenica, Pfizer, Sputnik V, SinoVac, Moderna, Sinopharm, have been described. In this case report, we present the first documented case of ADEM following the COVID-19 vaccine Ad26.COV2.S from Johnson & Johnson.
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Tác giả: Chakraborty, Prasenjit; Người hướng dẫn: -; Người tham gia: Kumar, Randhir; Karn, Sanjay; Srivastava, Ankit Kumar; Mondal, Priya (2023) - In early December 2019, an unusual pneumonia outbreak in Wuhan city, China, created an unprecedented and irreversible impact on the entire world 2/24/2023 12:58:00 PM. The symptoms of COVID-19 range from mild to severe, and include mainly fever, cough, and respiratory distress. Severe cases of pneumonia and hypoxemia result in considerable mortality (Rothan and Byrareddy 2020). The etiology has been linked to the new strain of coronavirus (SARS-CoV-2). According to the COVID-19 weekly epidemiological update by the World Health Organization (WHO), as of 9 May 2021, there have been a total of 163,965,336 COVID-19 cases with 3,397,147 fatalities (World Health Organization 2021). However, the new dynamics of the outbreaks seem highly variable among countries
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Tác giả: Muhammad, Yasin Ali; Người hướng dẫn: -; Người tham gia: - (2022) - At the time of this writing, SARS-CoV-2 has reportedly claimed the lives of millions of people worldwide. However, there is still disagreement concerning the origin of SARS-CoV-2, its true nature, and the extent of its pathogenicity. Thus, the purpose of this manuscript is to highlight and critically analyze these differences so that research efforts can be geared toward addressing these concerns.
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Tác giả: Choudhury, Priyanka Ray; Người hướng dẫn: -; Người tham gia: Saha, Tapoja; Goel, Sachin; Shah, Janvi Manish; Ganjewala, Deepak (2022) - The majority of pandemics are known to be a result of either bacteria or viruses out of which viruses seem to be an entity of growing concern due to the sheer number of yet unidentified and potentially threatening viruses, their ability to quickly evolve and transform, their ability to transfer and change from one host organism to another and the difficulty in creating safe vaccines on time.
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Tác giả: Giri, Simran; Người hướng dẫn: -; Người tham gia: Sen, Sanjukta; Singh, Rohan; Paul, Paramita; Sahu, Ranabir; Nandi, Gouranga; Dua, Tarun Kumar (2022) - The World Health Organization declared the outbreak of the novel coronavirus (COVID-19) as a global health emergency on January 30, 2020, and as a pandemic disease on March 11, 2020. This review highlights the international situation, risk factors, and related protections to be taken as prerequisite measures and probable treatment options for the COVID-19-infected population in the current scenario.
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Tác giả: Precious Ayorinde Akinnusi,; Người hướng dẫn: -; Người tham gia: Samuel Olawale Olubode,; Wasiu Adeboye Salaudeen, (2022) - The search for ideal drugs with absolute antiviral activity against SARS-CoV-2 is still in place, and attention has been recently drawn to natural products. Several molecular targets have been identified as points of therapeutic intervention. The targets used in this study include SARS-CoV-2 helicase, spike protein, RNA-dependent RNA polymerase, main protease, and human ACE-2. An integrative computer-aided approach, which includes molecular docking, pharmacophore modeling, and pharmacokinetic profiling, was employed to identify anthocyanins with robust multiple antiviral activities against these SARS-CoV-2 targets.
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Tác giả: Noor, Rashed; Người hướng dẫn: -; Người tham gia: Shareen, Saadia; Billah, Muntasir (2022) - The world has been suffering from the COVID-19 pandemic (officially declared by WHO in March 2020), caused by the severe acute respiratory β-coronavirus 2 (SARS-CoV-2) since the last week of December 2019. The disease was initially designated as a Public Health Emergency of International Concern on January 30, 2020. In order to protect the health of mass public, an array of research on drugs and vaccines against SARS-CoV-2 has been conducted globally. However, the emerging variants of SARS-CoV-2, i.e., Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) variants which evolved in late 2020 and the Omicron variant (B.1.1.529) which emerged in November 2021 along with its subvariant BA.2 which was first identified in India and South Africa in late December 2021, have ra...
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Tác giả: Davies-Bolorunduro, Olabisi Flora; Người hướng dẫn: -; Người tham gia: Fowora, Muinah Adenike; Amoo, Olufemi Samuel; Adeniji, Esther; Osuolale, Kazeem Adewale; Oladele, Oluwatobi; Onuigbo, Tochukwu Ifeanyi; Obi, Josephine Chioma; Oraegbu, Joy; Ogundepo, Oluwatobi; Ahmed, Rahaman Ademolu; Usman, Olagoke AbdulRazaq; Iyapo, Bosede Ganiyat; Dada, Adedamola Adejuwon; Onyia, Ngozi; Adegbola, Richard Adebayo; Audu, Rosemary Ajuma; Salako, Babatunde Lawal (2022) - A common complication of any respiratory disease by a virus could be a secondary bacterial infection, which is known to cause an increase in severity. It is, however, not clear whether the presence of some opportunistic pathogens called pathobionts contributes to the severity of the disease. In COVID-19 patients, undetected bacterial co-infections may be associated with the severity of the disease. Therefore, we investigated the implications of bacterial co-infections in COVID-19 cases.
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Tác giả: Adedeji, Akinbode A.; Người hướng dẫn: -; Người tham gia: Vijayakumar, Paul Priyesh (2022) - A direct quote from CDC’s Web site dated April 2021 reads, “It is possible for people to be infected (with SARS-CoV-2) through contact with contaminated surfaces or objects (fomites), but the risk is generally considered to be low.” How low the risk is, we do not know yet because there are no enough evidence-based empirical studies to support or counter this claim. Here is what we know, SAR-CoV-2, the virus that causes COVD-19 continues to pose a serious threat and has caused significant disruption to human activities, including food production since it became a pandemic in 2020. As of June 2022, 192 countries/regions have reported at least one case of the virus infection, and over 535 million cases have been reported globally (that is 294 million more since October 2021) with 85.5 ...
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Tác giả: Agarwal, Deepak; Người hướng dẫn: -; Người tham gia: Zafar, Imran; Ahmad, Syed Umair; Kumar, Sujit; Ain, Qurat ul; Sundaray, Jitendra Kumar; Rather, Mohd Ashraf (2022) - Ongoing pandemic outbreaks (COVID-19) and public health crises were intimidating across the globe with the appearance and spread of the 2019 novel coronavirus known as SARS-CoV-2. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) quickly spread from its origin in the Wuhan City of Hubei Province of the Republic of China, a country in East Asia, to the rest of the world (Wang et al. 2020a, b). Still, with small amounts of asymptomatic transmission between people, it spreads throughout the globe (Mohan et al. 2021). Coronaviruses (CoVs) are single-stranded, large, enveloped RNA viruses. They are spherical pleomorphic particles with bulbous surface projections. The CoVs genome size is from 29.8 to 29.9 kb (Su et al. 2016; Zheng et al. 2020). Virus particles have an average d...
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