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  • Computational analysis uncovers the deleterious SNPs along with the mutational spectrum of p53 gene and its differential expression pattern in pan-cancer

    • Authors: Alam, Saruar;  Advisor: -;  Participants: Sayem, Mohammad; Bello, Martiniano; Mou, Sadia Islam; Faruqui, Nairita Ahsan; Hossain, Faruk; Hasan, Md. Kamrul (2022)

  • The polymorphism data are available in several databases. NCBI dbSNP houses extensive data for different genes, and NCBI has the largest database that helps analyze single nucleotide polymorphisms. 581 SNPs have been found for cellular tumor antigen p53 (NCBI Reference Sequence: NP_000537.3). Among them, 420 SNPs were found to be missense or non-synonymous. Among 581, there were 435 SNPs in 3′UTR and 112 in 5′UTR regions. Only the missense, 3′ (3 prime), and 5′ (5 prime) UTR SNPs have been selected for further analysis.
  • BB

  • A combined 2-D and 3-D QSAR modeling, molecular docking study, design, and pharmacokinetic profiling of some arylimidamide-azole hybrids as superior L. donovani inhibitors

    • Authors: Ugbe, Fabian Audu;  Advisor: -;  Participants: Shallangwa, Gideon Adamu; Uzairu, Adamu; Abdulkadir, Ibrahim (2022)

  • Theoretical modeling of thirty-six arylimidamide-azole derivatives was conducted to establish a quantitative relationship between their structures and their inhibitory activities. As a result, a five-descriptor QSAR model was built (Eq. 13) with the descriptors well described in Table 4. The outcome of the internal and external validation assessment conducted on the built model is available in Table 5. The computed descriptors, observed activities (pIC50), and the predicted activities together with their residuals are presented in Table 6. Also, a plot of predicted activities versus experimental activities for the training set and test set is shown in Fig. 1, while Fig. 2 shows the plot of standardized residuals against experimental activities (pIC50).
  • BB

  • Nutritional properties of wheat flour supplemented with modified tacca (Tacca involucrata) flour for production of healthy biscuits

    • Authors: Ojewumi, Emmanuel Omotayo;  Advisor: -;  Participants: Omoba, Olufunmilayo Sade; Awolu, Olugbenga Olufemi (2022)

  • Proximate composition (g/100 g) of modified Tacca flour The proximate composition of the native and modified tacca flour is presented in Table 1. The moisture content of all the samples ranged from 7.34 to 10.14%; total ash from 1.19 to 2.59%; crude protein from 5.56 to 14.08%; crude fibre from 1.23 to 2.91%; and carbohydrate content from 68.86 to 82.10%. The energy values ranged from 347.69 to 381.06 kcal/ 100 g.
  • BB

  • Correction to: Assessment of phytotoxicity of selected botanical insecticides on treated cowpea (Vigna unguiculata) seed

    • Authors: Ogbonnaya, Ewa;  Advisor: -;  Participants: Rizwan, Ansari Ahmad; Bamidele, Emakoji Ile; Ayuba, Victoria (2022)

  • Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder
  • BB

  • Non-linear wave equations for free surface flow over a bump

    • Authors: Sakaguchi, Shino;  Advisor: -;  Participants: Nakayama, Keisuke; Vu, Thuy Thi Thu; Komai, Katsuaki; Nielsen, P. (2020)

  • This study aims to develop a new wave equation model by modifying the Fully-nonlinear and strongly-DispersiveSurfacewave(FDS)equations.Themodificationwasperformedbyapplyinga new expansion in a series of the vertical coordinate, zμ, to the velocity potential while a simple expansion in a series of z was applied to the FDS equations. Verification of the model was conductedby comparing withthe theoreticalsolutions ofsurfacesolitarywaves.Weappliedthe modifiedFDSequationstowave fieldsoverabumpunderconditionswithandwithoutcurrents, which agreed very well with the time series of wave heights and velocity obtained from laboratory experiments. The dispersion relationship computed using the normalized modified FDS equations also agreed very well with the theoretical solution when we gave the numbe...