In vitro antimicrobial activity of lignan from the stem bark of Strombosia grandifolia Hook.f. ex Benth

Abstract

The compound was active against tested microorganisms which included Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Salmonella typhi and Candida albicans using ciprofloxacin and terbinafine as standards. The zones of inhibition (ZOI) ranged between 11 and 17 mm for the compound against the microorganisms. The compound had a minimum inhibitory concentration (MIC) ranging from 0.75 to 3.0 mg/ml, and minimum bactericidal concentration (MBC) of 1.5, and a minimum fungicidal concentration (MFC) of 3.0 mg/ml. The lignan also showed antifungal activity against C. albicans. This experiment confirmed the efficacy of the lignan as a natural antimicrobial and suggested the possibility of employing it in drugs for the treatment of infectious diseases caused by the test organisms. This is the first report of the isolation of this compound from Strombosia grandifolia.