Computational evaluation of bioactive compounds from Vitis vinifera as a novel β-catenin inhibitor for cancer treatment

Adebesin, Ayomide Oluwadarasimi

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DC Field	Value	Language
dc.contributor.author	Adebesin, Ayomide Oluwadarasimi	vi
dc.contributor.other	Ayodele, Abigail Oluwakemi	vi
dc.contributor.other	Omotoso, Olabode	vi
dc.contributor.other	Akinnusi, Precious Ayorinde	vi
dc.contributor.other	Olubode, Samuel Olawale	vi
dc.date.accessioned	2023-03-31T02:37:29Z	-
dc.date.available	2023-03-31T02:37:29Z	-
dc.date.issued	2022	-
dc.identifier.issn	2522-8307	vi
dc.identifier.uri	http://tailieuso.tlu.edu.vn/handle/DHTL/12852	-
dc.description.abstract	This study features a computational approach to screen phytochemicals of V. vinifera against β-catenin, a therapeutic target protein that takes part in carcinogenesis through the wnt pathway by employing molecular docking, pharmacokinetics screening, MM/GBSA, and pharmacophore modeling approach. The molecular docking and binding energy study (Figs. 2 and 3) predicted seven compounds as lead compounds that show a better inhibitory potential when compared with the standard compounds, leucovorin Calcium and Xeloda.	vi
dc.description.uri	https://link.springer.com/article/10.1186/s42269-022-00872-3	vi
dc.language	en_US	vi
dc.relation.ispartofseries	Bulletin of the National Research Centre, Volume 46 (2022), Article number: 183	vi
dc.subject	Wnt/β-catenin signaling pathway	vi
dc.subject	Vitis vinifera	vi
dc.subject	Molecular docking	vi
dc.subject	ADMET	vi
dc.subject	MM/GBSA	vi
dc.subject	Pharmacophore modeling	vi
dc.title	Computational evaluation of bioactive compounds from Vitis vinifera as a novel β-catenin inhibitor for cancer treatment	vi
dc.type	BB	vi
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