BROWSE

AUTHOR PROFILE

Browsing by Author Madanagopal, Premnath

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 2 of 2
  • BB

  • Construction and validation of a multi-epitope in silico vaccine model for lymphatic filariasis by targeting Brugia malayi: a reverse vaccinology approach

    • Authors: Madanagopal, Premnath;  Advisor: -;  Participants: Muthusamy, Sathya; Prince, Prabhu Rajaiah; Pradhan, Satya Narayan (2023)

  • Prediction of T cell epitopes and prioritization In this study, CTL epitopes were predicted using the IEDB MHC-I processing tool, whereas HTL epitopes were predicted using the IEDB MHC-II Binding Predictions tool and both types of T cell epitopes were predicted by the SMM approach against a set of human reference HLAs with adjusted IC50 value less than 50 nM. A total of 15 CTL epitopes and 3 HTL epitopes were shortlisted for eight selected antigenic proteins by applying several immunological filters as shown in Tables 1 and 2. All of the optimal epitopes, as well as their antigenicity, positioning and binding alleles, are documented in Tables 3 and 4. In addition, for the best possib...
  • BB

  • In silico prediction and structure-based multitargeted molecular docking analysis of selected bioactive compounds against mucormycosis

    • Authors: Madanagopal, Premnath;  Advisor: -;  Participants: Ramprabhu, Nagarjun; Jagadeesan, Rahul (2022)

  • During the second wave of the COVID-19 pandemic, an unusual increase in cases of mucormycosis was observed in India, owing to immunological dysregulation caused by the SARS-CoV-2 and the use of broad-spectrum antibiotics, particularly in patients with poorly controlled diabetes with ketoacidosis to have contributed to the rise, and it has been declared an epidemic in several states of India. Because of the black colouring of dead and dying tissue caused by the fungus, it was dubbed "black fungus" by several Indian media outlets. In this study, attempts were taken to unmask novel therapeutic options to treat mucormycosis disease. Rhizopus species is the primary fungi responsible for 70...