BBAuthors: Goswami, Pritam; Advisor: -; Participants: Chatterjee, Debasmita; Ghosh, Sayak; Paira, Krishnendu; Das, Satadal (2022)
Delta SARS-CoV-2 spike protein RBD antigen, in concentration of 10 µg/mL, increases IFN-α, more than 1500 times. It also increases IFN-ß about 150 times, and TGF-ß about 74 times. Increase in IFN-ƴ, IL-6, IL-8, IL-10, and IL-1ß was insignificant.When after administration of Bryonia 6C, the chick embryo was challenged with antigen, only interferons are moderately upregulated along with IL-6. Although increase in interferons after 48 h is beneficial to the embryo, an increase in IL-6 may lead to initiation of upsurge of pro-inflammatory cytokines. This may be detrimental to the normal physiological activities of the embryo, and thus, the preventive role of Bryonia 6C is questionable. In... 
