BBAuthors: Adawara, Samuel Ndaghiya; Advisor: -; Participants: Shallangwa, Gideon Adamu; Mamza, Paul Andrew; Abdulkadir, Ibrahim; Abdulkadir, Ibrahim (2022)
Dengue virus (DENV) infection is spreading rapidly, especially in the subtropical and tropical regions, placing a huge percentage of the global population at risk and causing repeated outbreaks. DENV protease inhibition has been suggested as a viable therapeutic strategy. Using a computer-aided design approach and the structure-based drug design approach, ten 1, 2, 4-oxadiazole derivatives were designed based on the lead template (34) from our prior study. The design involved the substitution at the phenyl pharmacophore of the lead with methylamine, hydroxyl, and methoxy groups. To compare the anti-DENV efficacy of the optimized designed compounds to the template and other DENV refere... 
