Assessment of the antibacterial effect of Khaya senegalensis on some Gram-negative bacteria

Abstract

The data collected indicate that the bacterial strains tested (Salmonella Typhimurium ATCC 14028, Escherichia coli ATCC 25922, Shigella spp. and Salmonella spp.) were sensitive to the extracts of Khaya senegalensis (Desr.) A.Juss. (aqueous and hydro-ethanol) to varying degrees. The hydro-ethanolic extract was active on all strains with a MIC of 25 mg/mL coupled with a bactericidal effect. The aqueous extract was only active on the Salmonella spp. strain. Membrane permeability test data show that Khaya senegalensis extracts affect the bacterial strains tested by attacking the stability of their outer membrane. This potential indicated by the high percentage of membrane destabilization of the bacteria is significantly (p < 0.05) better than that of cefixime used as a reference.