Item Infomation
Title: | QSAR studies of BBR analogues against coxsackievirus B1 |
Authors: | Obadawo, Babatunde Samuel |
Participants: | Asogwa, Uchenna Ali, Abdualbaset Ahmed |
Issue Date: | 2022 |
Series/Report no.: | Bulletin of the National Research Centre, Volume 46 (2022), Article number: 14 |
Abstract: | Coxsackievirus group B (CVBs) are common enteroviruses associated with several diseases from etiologically to inflammatory cardiomyopathies and constitute a severe cause of mortality in newborn resulting in severe meningitis, fulminant infection, myocarditis, and encephalitis. While Berberian (BBR) is an effective antivirus and possesses potentials of suppressing CVB replication, Zeng et al. explored a structural modification of BBR by incorporating a substituted primary amine enhance antiviral potency and safety. Based on data set from Zeng et al., we attempted to propose a QSAR model that can predict the bioactivity of unknown compounds as anti-CVB1. |
URI: | http://tailieuso.tlu.edu.vn/handle/DHTL/12625 |
Source: | https://link.springer.com/article/10.1186/s42269-022-00698-z |
ISSN: | 2522-8307 |
Appears in Collections: | Tài liệu mở |
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