Quassia amara bioactive compounds as a Novel DPP-IV inhibitor: an in-silico study

Abstract

Diabetes mellitus is a significant upstream event in terms of molecular pathophysiology, with a slew of sequelae including immunological, metabolic, and genetic malformations, as well as a common symptom of interest, persistently high blood glucose levels (Egan and Dinnen 2019; Yaribeygi et al. 2020).

The consequences of untreated diabetic cases, according to the World Health Organization (2019), include retinopathy, nephropathy, and neuropathy, among other issues. Patients with diabetes, on the other hand, are at risk for heart, peripheral artery, and cerebrovascular disease, obesity, cataracts, erectile dysfunction, and nonalcoholic fatty liver disease, to name a few.