Coumarin and fatty alcohol from root bark of strychnos innocua (delile): isolation, characterization and in silico molecular docking studies

Abstract

Compounds isolated from plants have enormous potential in the development of new drugs (Sasidharan et al. 2011). In general, plants can be found all over the world, and their parts (leaves, stems, roots, fruit, and flowers) are employed in a variety of uses, including medicine (Umaru et al. 2019).

The phytochemical composition and secondary metabolites of plants such as coumarin and fatty alcohols contain active therapeutic components and are associated with their pharmacological potential (Mondal et al. 2019; Uttu et al. 2022). Umbelliferone (7-hydroxycoumarin) is sometimes utilized as a fluorophore. It has a large π–π conjugated system that allows it to be used as a fluorescent sensor for a variety of biological applications (Raunio et al. 2020), such as antidiarrheal, antiulcerogenic, antibacterial, mutagenic, and antioxidant activities (Cruz and de-Figueriredo G. F., Pedro L. P., Amorin Y. M., Andrade J. T., Passos T. F. and Araujo M. G. D. 2020), whereas 2,13-octadecadien-1-ol was identified as one of the major phytochemical compounds in Epipremnum aureum and possesses diuretic, antimicrobial, antiulcer, anti-inflammatory, antioxidant, and pesticide activities