Isothermal microcalorimetry (IMC) calscreener: automated peculiarities of antimicrobial therapy and metabolism depth of multidrug resistant bacteria

Abstract

The swift establishment of the cause/origin of a microbial infection and commencement of pathogen-specific chemotherapy stands as the key foundation for the effective treatment of infections. Even with the advancement in technology engaged in the detection of pathogenic microorganisms and their resistant genes (DNA-based assays), the conventional cultural techniques and susceptibility testing are still employed as reference for bacteriological studies of infections (Tellapragada et al. 2020). Commonly used conventional assays by laboratories globally are disc diffusion test (DDT) and broth micro-dilution (BMD) assays for defining the susceptibility of the pathogens and determination of the minimum inhibitory concentration (MIC) of antimicrobial agents.