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Results 1-9 of 9 (Search time: 0.235 seconds).
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  • Early-pandemic wastewater surveillance of SARS-CoV-2 in Southern Nevada: Methodology, occurrence, and incidence/prevalence considerations

    • Authors: Gerrity, D.;  Advisor: -;  Participants: Papp, K.; Stoker, M.; Sims, A.; Frehner, W. (2021)

  • The current study aimed to compare the performance of virus recovery and detection methods, detect and quantify SARS-CoV-2 genetic material in two Southern Nevada sewersheds from March–May 2020, and better understand the potential link between COVID-19 incidence/prevalence and wastewater concentrations of SARS-CoV-2 RNA. SARS-CoV-2 surrogate recovery (0.34%–55%) and equivalent sample volume (0.1 mL–1 L) differed between methods and target water matrices, ultimately impacting method sensitivity and reported concentrations. Composite sampling of influent and primary effluent resulted in a ∼10-fold increase in concentration relative to corresponding grab primary effluent samples, presumably highlighting diurnal variability in SARS-CoV-2 signal. Detection and quantification of four SARS...
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  • The neuropathological impact of COVID-19: a review

    • Authors: Fouad, Ghadha Ibrahim;  Advisor: -;  Participants: - (2021)

  • The neuroinvasive potential of SARS-CoV-2 might contribute to its fatal behavior. Understanding the underlying mechanisms of this novel neuropathogen might contribute to the development of effective therapeutic strategies. The manifestations of neural damage in COVID-19 patients ranged from headache to severe encephalopathy and progression of preexisting neural disorders, it is speculated that neuroinvasion is strongly linked to the fatal respiratory dysfunction. The underlying neuropathological impact of emerging pneumonia (COVID-19) is still unclear.
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  • Luteolin and abyssinone II as potential inhibitors of SARS-CoV-2: an in silico molecular modeling approach in battling the COVID-19 outbreak

    • Authors: Shawan, Mohammad Mahfuz Ali Khan;  Advisor: -;  Participants: Halder, Sajal Kumar; Hasan, Md. Ashraful (2021)

  • Out of the forty-three flavonoids, luteolin and abyssinone II were found to develop successful docked complex within the binding sites of target proteins in terms of lowest binding free energy and inhibition constant. The root mean square deviation and root mean square fluctuation values of the docked complex displayed stable interaction and efficient binding between the ligands and target proteins. Both of the flavonoids were found to be safe for human use and possessed good drug likeness properties and target accuracy.
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  • Phylogenetic and full-length genome mutation analysis of SARS-CoV-2 in Indonesia prior to COVID-19 vaccination program in 2021

    • Authors: Nidom, Reviany V.;  Advisor: -;  Participants: Indrasari, Setyarina; Normalina, Irine; Nidom, Astria N.; Afifah, Balqis; Dewi, Lestari; Putra, Andra K.; Ansori, Arif N. M.; Kusala, Muhammad K. J.; Alamudi, Mohammad Y.; Nidom, Chairul A. (2021)

  • All data of the isolates were extracted from the Global Initiative on Sharing All Influenza Data (GISAID) EpiCoV database. CoVsurver platform was employed to investigate the full-length genome mutation analysis of all isolates. This study also focused on the phylogeny analysis in unlocking the mutation of S protein in Indonesian SARS-CoV-2 isolates. WIV04 isolate that was originated from Wuhan, China was used as the virus reference according to the CoVsurver default. The result showed that a full-length genome mutation analysis of 166 Indonesian SARS-CoV-2 isolates was successfully generated. Every single mutation in S protein was described and then visualized by utilizing BioRender platform. Furthermore, it also found that D614G mutation appeared in 103 Indonesian SARS-CoV-2 isolat...
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  • Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity

    • Authors: Veerabathiran, Ramakrishnan;  Advisor: -;  Participants: Ragunath, Barath; Kaviarasan, Vaishak; Mohammed, Vajagathali; Ahmed, Shiek S. S. J. (2021)

  • SARS-CoV-2 is an extremely infectious and transferrable virus that develops severe conditions like respiratory syndrome, high blood pressure and weakens the immune system. Coronavirus falls under the Coronaviridae family and Beta coronavirus genus. Affected individuals will encounter problems starting with fever followed by severe complications like SARS, ARDS, and many others. These SARS-CoV and MERS-CoV enter the host cells by the endosomal pathway, and about 16 non-structural proteins are involved in assembling the viral RNA synthesis complex. They possess a positive-sense single-stranded RNA, and about four major genes are mainly associated with the development of ASRD, SARS, and other respiratory problems. Susceptibility of these four major genes such as ACE2, IL-2, 7 and 10, T...
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  • In silico identification of compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targets

    • Authors: Duru, Chidi Edbert;  Advisor: -;  Participants: Duru, Ijeoma Akunna; Adegboyega, Abayomi Emmanuel (2021)

  • The binding affinity of caryophyllene oxide was the highest on 3CLpro (− 6.0 kcal/mol), NSP3 (− 6.3 kcal/mol), NSP9 (− 6.3 kcal/mol), and RDRP (− 6.9 kcal/mol) targets, while α-bergamotene gave the best binding affinity on RPIA (5.7 kcal/mol) target. The binding affinity of β-bisabolene on the ACE2 target (− 8.0 kcal/mol) was almost the same as Remdesivir (− 8.1 kcal/mol). The ADMET properties of these three phytochemicals showed that they are good drug leads for these SARS-CoV-2 receptors.
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  • An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

    • Authors: Hembram, Padmalochan;  Advisor: -;  Participants: - (2021)

  • Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak.
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  • Recent updates on the possible reasons for the low incidence and morbidity of COVID-19 cases in Africa

    • Authors: Tsinda, Emmanuel Kagning;  Advisor: -;  Participants: Mmbando, Gideon Sadikiel (2021)

  • The COVID-19 respiratory illness caused by the SARS-CoV-2 has been a major cause of morbidity and mortality worldwide since the first reported case in Wuhan, China. A year has passed since pandemic began, and the reasons for different COVID-19 burden variation across continents keep puzzling the general public.
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